 | Saltwash Elixir | Items | Any dungeon |
 | Sanctuary | Effects | |
| Sanctuary | Abilities | |
 | Scholar's Headscarf | Items | WyrmheartXul, The Blood Monolith |
 | Scorch | Abilities | |
| Scorch | Effects | |
 | Scorched | Effects | |
 | Scribe's Leggings | Items | Cithrel's FallXul, The Blood Monolith |
 | Sea-Sprayed Wraps | Items | Sailor's AbyssXul, The Blood Monolith |
 | Seal of Eldrin Swiftness | Items | WyrmheartXul, The Blood Monolith |
 | Searing Blaze | Abilities | |
| Searing Blaze | Effects | |
 | Secondhand Cloak | Items | Equipment Vendor |
 | Shadowstone Ring | Items | Equipment Vendor |
 | Shaped Antler of Akari | Items | Everdawn GroveXul, The Blood Monolith |
 | Shiny Rocks | Items | Equipment Vendor |
 | Silkthreaded Slippers | Items | Silken HollowXul, The Blood Monolith |
| Sinbinding Stone | Items | Any dungeon |
 | Siren’s Bauble | Items | Sailor's AbyssXul, The Blood Monolith |
 | Skittering Collar | Items | Silken HollowXul, The Blood Monolith |
 | Slaughtervine Loop | Items | Equipment Vendor |
| Slippers of Frost | Items | Cithrel's FallXul, The Blood Monolith |
 | Slow Burn | Talents | |
| Snow-Caked Boots | Items | Scryer's PeakXul, The Blood Monolith |
 | Snowmelt Robe | Items | Ransack of DrakheimXul, The Blood Monolith |
 | Soaked Gloves | Items | Ruins of RegathXul, The Blood Monolith |
 | Sodden Bloodmantle | Items | Ruins of RegathXul, The Blood Monolith |
| Soot Scarred Legwraps | Items | StormwatchXul, The Blood Monolith |
| Soot-Stained Boots | Items | StormwatchXul, The Blood Monolith |
 | Soul-Cursed Signet | Items | Empyrean SandsXul, The Blood Monolith |
 | Spirit of Heroism | Effects | |
| Spirit of Heroism | Effects | |
| Spirit of Heroism | Effects | |
 | Spontaneous Combustion | Talents | |
| Spontaneous Combustion | Abilities | |
| Squelching Mitts | Items | Sailor's AbyssXul, The Blood Monolith |
 | Stormsentinel Wristband | Items | Godfall QuarryXul, The Blood Monolith |
 | Stunned | Effects | |
 | Tarnished Amulet | Items | Equipment Vendor |
 | Tarnished Braclet | Items | Scryer's PeakXul, The Blood Monolith |
 | Tattered Oilcloth | Items | Wraithtide VaultXul, The Blood Monolith |
| The Magistrate's Epaulets | Items | WyrmheartXul, The Blood Monolith |
 | Threadbare Boots | Items | Equipment Vendor |
| Threadbare Bracers | Items | Equipment Vendor |
 | Threadbare Epaulets | Items | Equipment Vendor |
 | Threadbare Gloves | Items | Equipment Vendor |
 | Threadbare Hood | Items | Equipment Vendor |
 | Threadbare Pants | Items | Equipment Vendor |
 | Threadbare Robe | Items | Equipment Vendor |
| Titanslayer's Drape | Items | Godfall QuarryXul, The Blood Monolith |