| Twin Souls: Army of One | Effects | |
| Undulating Spirit | Legendary Powers | |
| Undying Heart | Relic Passives | |
| Unholy Pulse | Abilities | |
| Unrelenting Thicket | Legendary Powers | |
| Upheaval | Abilities | |
| Upheaval | Effects | |
| Upheaval | Abilities | |
| Ursa's Might / Wolf's Guille / Vampire's Cunning | Effects | |
| Vanguard of Vengeance | Effects | |
| Vanguard's Advance | Legendary Powers | |
| Vanguard's Resolve | Effects | |
| Vanguard's Resolve - II | Effects | |
| Vein Constriction | Effects | Han-Eth, Sentry of Xul |
| Vengeful Soul | Effects | |
| Vessel of Vel'korath | Creatures | Xul, The Blood Monolith |
| Volatile Orb | Effects | |
| Volatile Poison | Effects | |
| Vortex | Abilities | Overseer Yrsa |
| Vortex (Yrsa) | Effects | Overseer Yrsa |
| War Horn | Abilities | |
| War Machine | Creatures | |
| Warrior | Creatures | |
| Whirlwind | Abilities | |
| Whirlwind | Effects | |
| Whispering Core | Creatures | |
| White Witch's Ritual | Abilities | Eira the White Witch |
| White Witch's Ritual | Abilities | Eira the White Witch |
| Wildroot Thorns | Abilities | Slavetrader Brull |
| Wildroot Thorns | Effects | |
| Wildroot Thorns | Effects | Slavetrader Brull |
| Wildroot Thorns | Effects | |
| Willful Momentum | Effects | |
| Windup Mouse | Abilities | |
| Windup Mouse | Effects | |
| Winter Rune Shield | Effects | |
| Winter's Blessing | Effects | |