| Ruby Storm | | |
 | Ruinous Starfall | Sin-Magir | Magic / Shadow |
 | Rune of Detonation | Deceitful Scholar | Magic / Arcane |
 | Rune of the White Witch | Eira the White Witch | Magic / Frost |
 | Rupture Earth | Bleachbone Bouncer | Magic / Water |
 | Sacrificial Pyre | Moar'gore, Master of Sacrifice | Magic / Fire |
 | Salted Blade | Saltsworn Scallywag | |
| Salting Wound | | Physical |
 | Sanguine Brand | Overlord Varux | Physical |
 | Sanguine Claws | Stalking Grim | |
 | Sanguine Maelstrom | | Physical |
 | Sanguine Might | Blood Orb | Magic |
 | Sanguine Offering | Bloodrite Chanter | Magic / Blood |
 | Sanguine Ritual | Sanguine Oracle | Magic / Blood |
| Sapphire Aurastone | | |
 | Scan | | |
| Scorch | | |
 | Searing Beam | | Magic / Holy |
| Searing Beam | Godfall Wardstone | Magic / Holy |
 | Searing Fissure | Xurath, Fist of the Warden | Magic / BloodPhysical |
 | Searing Veins | Ascended Bloodweaver | Magic / Blood |
 | Seek and Destroy | Xurath, Fist of the Warden | Physical |
 | Seek Blood | | Physical |
 | Seeping Reliquary | Xurath, Fist of the Warden | Magic / Frost |
 | Select Ball Mover | Bael'Aurum | |
 | Sever Soul | Deathless Katrine | |
| Sever Souls | Deathless Katrine | |
| Shackle | | |
 | Shackle Blast | Scuttlejack Cannoneer | |
| Shackle Chuck | Bleakfrost Slaver | |
| Shackle Chuck | Cruel Slaver | |
 | Shadow Bolt | Nightmist Whisperer | Magic / Frost |
 | Shadow Bolt | Nightbound Magi | Magic / Necromancy |
 | Shadow Bolt | Profane Defiler | Magic / Shadow |
| Shadow Bolt | Invoker | Magic / Shadow |
 | Shadow Conduit | Auga Handhafi the Blind | Magic / Shadow |
| Shadow Lob | Corrupted Totemic | Magic / Frost |
 | Shadow Slam | Shadow of Ulmorgat | Magic / Shadow |
 | Shadowcrash | | Magic / Shadow |
 | Shadowgreed Eclipse | Bael'Aurum | |
| Shadowmeld | | |
 | Shake It Off | Sanguine Echo | Magic / Blood |
 | Shardling Explosion | | |
 | Shared Health | Blood Orb | |
 | Shatter | Raging Ice Elemental | |
| Shatter | Godstone Goliath | Magic / Nature |
 | Shattering Barrier | Icewyrm Sentinel | |
| Shattering Barrier | Icewyrm Sentinel | Magic / Frost |
 | Shattering Ice | Eira the White Witch | Magic / Frost |
 | Shatterstrike | Ancient Koros | Magic / Frost |