| Carries none |
 | Sanguine Maelstrom | | Physical |
 | Sanguine Might | Blood Orb | Magic |
 | Sanguine Offering | Bloodrite Chanter | Magic / Blood |
 | Sanguine Ritual | Sanguine Oracle | Magic / Blood |
| Sapphire Aurastone | | |
 | Scan | | |
 | Scorch | | |
 | Scorch |  Ardeos | Magic / Fire |
 | Searing Beam | | Magic / Holy |
| Searing Beam | Godfall Wardstone | Magic / Holy |
 | Searing Blaze | Ardeos | Magic / Fire |
 | Searing Fissure | Xurath, Fist of the Warden | Magic / BloodPhysical |
 | Searing Veins | Ascended Bloodweaver | Magic / Blood |
 | Seek and Destroy | Xurath, Fist of the Warden | Physical |
 | Seek Blood | | Physical |
 | Seeping Reliquary | Xurath, Fist of the Warden | Magic / Frost |
 | Seeting Burst |  Mara | |
 | Select Ball Mover | Bael'Aurum | |
 | Sentinel's Bastion | | |
| Sentinel's Bastion - II | | |
 | Serenity |  Meiko | Magic |
 | Sever Soul | Deathless Katrine | |
| Sever Souls | Deathless Katrine | |
| Shackle | | |
 | Shackle Blast | Scuttlejack Cannoneer | |
| Shackle Chuck | Cruel Slaver | |
 | Shadow Bolt | Nightbound Magi | Magic / Necromancy |
 | Shadow Bolt | Profane Defiler | Magic / Shadow |
| Shadow Bolt | Invoker | Magic / Shadow |
 | Shadow Lord's Aura | Emissary of the Shadow Lord | |
 | Shadow Ward | Mara | |
 | Shadowcrash | | Magic / Shadow |
 | Shadowgreed Eclipse | Bael'Aurum | |
| Shadowmeld | | |
 | Shake It Off | Sanguine Echo | Magic / Blood |
 | Shardling Explosion | | |
 | Shared Health | Blood Orb | |
 | Shatter | Raging Ice Elemental | |
 | Shatter | Godstone Goliath | Magic / Nature |
 | Shatter Earth | Meiko | Physical |
 | Shattering Barrier | Icewyrm Sentinel | |
| Shattering Barrier | Icewyrm Sentinel | Magic / Frost |
 | Shattering Ice | Eira the White Witch | Magic / Frost |
 | Shatterstrike | Ancient Koros | Magic / Frost |
| Shield of Pain | | |
 | Shield Slam |  Helena | Physical |
 | Shield Throw | Helena | Physical |
 | Shields Up | Helena | |
 | Shining Halo |  Xavian | Physical |
 | Shockwave | Helena | Physical |