 | Corrupted Blood | | |
| Corrupted Earth | Whispering Core | |
 | Corrupting Prayer | Fallen Cleric | Magic / Necromancy |
 | Crackling Bolt | Stormscreamer | Magic / Frost |
 | Crackling Inferno | Ardeos | |
| Crash Gate | Boss Siege Graveyard | |
 | Creeping Death | Slavetrader Brull | Magic / Nature |
| Creeping Decay | Slavetrader Brull | Magic / Nature |
 | Crescent Cleave | Gravebreaker Brute | Magic / Water |
 | Crimson Crucifix | Overlord Varux | Physical |
| Crippling Shot | | |
 | Crush Armor | Barbarous Lasher | Physical |
 | Crushing Blows | Ghorn the Avalanche | Physical |
| Crushing Blows | Ghorn the Giant | Physical |
 | Crushing Darkness | Xurath, Fist of the Warden | Physical |
 | Crushing Orb | Orb of Bael'Aurum | |
 | Crystaline Corruption | Skittershard | Magic |
| Crystalline Corruption | Skittershard | Magic / Nature |
 | Crystalline Slam | Whispering Core | Physical |
 | Culling Strike | Tariq | Physical |
 | Cure Ailment | Sylvie | Magic / Nature |
 | Curse of Drowning | Vengeful Shade | Magic / Shadow |
 | Cursed Lightning | | |
| Cursed Reflection | Whispering Core | |
 | Cursed Treasure | Bael'Aurum | |
 | Cyclone | Meiko | Physical |
 | Dark Cleave | Spectre of Avarice | Physical |
| Dark Volley | Reanimated Archer | Physical |
 | Darkstar Ruin | Ruinous Star | |
 | Dawnbreaker Orb | Vigour | Magic / Holy |
 | Dawnflare | Vigour | Magic / Holy |
 | Deactivate Sanguine Frenzy | | |
 | Deadly Shot (old) | | Physical |
 | Death's Arc | | Physical |
 | Deathrattle | Carrion Horror | |
 | Decietful Gifts | Krumbug the Naughty | Physical |
 | Decimate | Gravebreaker Brute | Physical |
 | Decree of the Sun | Xavian | Physical |
 | Decripify | Eldrin Chronomancer | |
| Deluge | | |
 | Demonic Lash | Diabolical Hellcaller | Magic / Demonic |
 | Desperate Prayer | Defending Cleric | Magic / Holy |
| Destroying | | |
 | Detonate | Ardeos | Magic / Fire |
| Detonate | Anomalous Orb | |
| Devastate | | |
 | Devastate | | |
 | Devour | Vexira, Mother of Nightmares | Physical |
 | Devouring Darkness | Nightmist Fiend | Magic / Shadow |
| Devouring Darkness | Nightmist Fiend | Magic / Shadow |