 | Seeping Reliquary | Xurath, Fist of the Warden | Magic / Frost |
 | Select Ball Mover | Bael'Aurum | |
 | Sever Soul | Deathless Katrine | |
| Sever Souls | Deathless Katrine | |
| Shackle | | |
 | Shackle Blast | Scuttlejack Cannoneer | |
| Shackle Chuck | Cruel Slaver | |
 | Shadow Bolt | Nightbound Magi | Magic / Necromancy |
 | Shadow Bolt | Profane Defiler | Magic / Shadow |
| Shadow Bolt | Invoker | Magic / Shadow |
 | Shadowcrash | | Magic / Shadow |
 | Shadowgreed Eclipse | Bael'Aurum | |
| Shadowmeld | | |
 | Shake It Off | Sanguine Echo | Magic / Blood |
 | Shardling Explosion | | |
 | Shared Health | Blood Orb | |
 | Shatter | Raging Ice Elemental | |
 | Shatter | Godstone Goliath | Magic / Nature |
 | Shattering Barrier | Icewyrm Sentinel | |
| Shattering Barrier | Icewyrm Sentinel | Magic / Frost |
 | Shattering Ice | Eira the White Witch | Magic / Frost |
 | Shatterstrike | Ancient Koros | Magic / Frost |
 | Shoot | Savage Hunter | |
 | Shoot | Scuttlejack Cannoneer | Physical |
 | Shoot | Soulpowder Buccaneer | Physical |
| Shoot | Tundra Stalker | Physical |
 | Shoot | Nezari Bolter | |
 | Shoot |  Elarion | Physical |
 | Shoot | Fangstrider | Physical |
 | Shred | Mounted Raider | Physical / Bleed |
| Shred | Bloodfang Panther | Physical |
| Shred | Bloodfang Panther | Physical |
| Sinister Vessels | Vel’korath the Sanctified, Vision of the Covenant | Magic / Shadow |
 | Sinnari's Judgement | Sin-Magir | Magic / Shadow |
 | Sinnari's Wrath | Acolyte of Sinnari | Magic / Shadow |
| Sinnari's Wrath | Acolyte of Sinnari | Magic / Shadow |
| Skullsaber Roar | | |
 | Sky Zapper | Stormscreamer | Magic / Lightning |
| Sky Zapper | Stormscreamer | Magic / Lightning |
 | Slam | | Physical |
| Slam | Heig the Chained | |
| Slash Claws | Jungle Stalker | Physical |
| Slaughter | | Physical |
 | Slicing Blades | Blade of Cithrel | Physical |
| Soul Bolt | Caster | |
| Soul Transfusion | | |
| Soulflame Bulwark | | |
 | Soulpiercer | | Physical |
 | Soulpiercer | Dunesnare Hunter | Physical |
 | Soulpowder Cannon | Deathless Katrine | |